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KMID : 0380620090410040380
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 4 p.380 ~ p.385
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The Comparison of Extraction Process for Enhancementof Immunomodulating Activities of Ulva pertusa kjellman
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Han Jae-Gun
Ha Ji-Hye
Choi Young-Beom
Ko Jung-Rim
Kang Do-Hyung
Lee Hyeon-Yong
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Abstract
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The purpose of this study was to investigate the immunomodulatory effect of Ulva pertusa kjellman extractafter undergoing a low temperature and high-pressure extraction process. First, the extracts obtained under the extractionconditions of 150 MPa and 80oC showed a relatively high antioxidant activity, with 90% super oxide radical activitycompared to the extracts from conventional extraction process with water at 100oC. This extract also improved the growthof both human immune B and T cells up to 14.5×104 cells/mL and 14.2×104 cells/mL compared to 9.1×104 cells/mL inadding the extracts from conventional processes. It was found that the extracts obtained at 100 MPa and 60oC showedbetter activities in NK cell growth and NO production from macrophage as 11.8×102 cells/mL and 30.0μM. Overall, theextracts from high pressure and low temperature extraction process had relatively higher immune activation activity,possibly because the low temperature and high pressure extraction process may have higher yields of active compoundsand have less damage to useful ingredients from relatively weak marine natural resources, such as Ulva pertusa kjellmannthan that from the conventional extraction system.
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KEYWORD
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Ulva pertusa kjellmann, high-pressure extracts, immuno modulating activity
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